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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CXCR3
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  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CXCR3

Gene description

Chemokine (C-X-C motif) receptor 3

Protein class

CD markers
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (RPMI-8226)
HPA (normal tissue):Tissue enhanced (lymph node)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in a subset of leukocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 1 antibody.
HPA045942
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable), melanoma (favourable) and head and neck cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Melanoma p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA045942

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of thyroid and colorectal cancers displayed moderate cytoplasmic staining with additional membranous positivity in liver cancers. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

CXCR3 (HGNC Symbol)

Synonyms

CD183, CKR-L2, CMKAR3, GPR9, IP10-R, MigR

Description

Chemokine (C-X-C motif) receptor 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

Chromosome

X

Cytoband

q13.1

Chromosome location (bp)

71615916 - 71618517

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186810 (version 83.38)

Entrez gene

2833

UniProt

P49682 (UniProt - Evidence at protein level)

neXtProt

NX_P49682

Antibodypedia

CXCR3 antibodies

PROTEIN BROWSER

CXCR3-001
CXCR3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CXCR3-001
ENSP00000362795
ENST00000373691
P49682 [Direct mapping]
C-X-C chemokine receptor type 3
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0001525 [angiogenesis]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0002685 [regulation of leukocyte migration]
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008284 [positive regulation of cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010818 [T cell chemotaxis]
GO:0016021 [integral component of membrane]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0016525 [negative regulation of angiogenesis]
GO:0019722 [calcium-mediated signaling]
GO:0019956 [chemokine binding]
GO:0019958 [C-X-C chemokine binding]
GO:0030816 [positive regulation of cAMP metabolic process]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050921 [positive regulation of chemotaxis]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0071954 [chemokine (C-C motif) ligand 11 production]
GO:1900118 [negative regulation of execution phase of apoptosis]
GO:1900119 [positive regulation of execution phase of apoptosis]
Show all
415 aa
45.5 kDa
No 7
CXCR3-002
ENSP00000362797
ENST00000373693
P49682 [Direct mapping]
C-X-C chemokine receptor type 3
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0001525 [angiogenesis]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0002685 [regulation of leukocyte migration]
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0019956 [chemokine binding]
GO:0019958 [C-X-C chemokine binding]
GO:0030816 [positive regulation of cAMP metabolic process]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050921 [positive regulation of chemotaxis]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0071954 [chemokine (C-C motif) ligand 11 production]
GO:1900118 [negative regulation of execution phase of apoptosis]
GO:1900119 [positive regulation of execution phase of apoptosis]
Show all
368 aa
40.7 kDa
No 7

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