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KRT16

GENERAL INFORMATION

Gene name

 KRT16

Gene description

 Keratin 16, type I

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (cervical cancer, head and neck cancer, melanoma)
HPA (cell line):Cell line enriched (hTCEpi)
HPA (normal tissue):Group enriched (esophagus, tonsil)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in squamous epithelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB000136
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (cervical cancer, head and neck cancer, melanoma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
CAB000136

GENE INFORMATION

Gene name

 KRT16 (HGNC Symbol)

Synonyms

 NEPPK

Description

 Keratin 16, type I (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 41609778 - 41615899

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186832 (version 83.38)

Entrez gene

 3868

UniProt

 P08779 (UniProt - Evidence at protein level)

neXtProt

 NX_P08779

Antibodypedia

 KRT16 antibodies

PROTEIN BROWSER
KRT16-001
KRT16-003
KRT16-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT16-001
ENSP00000301653
ENST00000301653
P08779 [Direct mapping]
Keratin, type I cytoskeletal 16
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002009 [morphogenesis of an epithelium]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005856 [cytoskeleton]
GO:0005882 [intermediate filament]
GO:0006954 [inflammatory response]
GO:0007010 [cytoskeleton organization]
GO:0007568 [aging]
GO:0008283 [cell proliferation]
GO:0008544 [epidermis development]
GO:0030216 [keratinocyte differentiation]
GO:0030336 [negative regulation of cell migration]
GO:0031424 [keratinization]
GO:0042633 [hair cycle]
GO:0045087 [innate immune response]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0051546 [keratinocyte migration]
GO:0061436 [establishment of skin barrier]
GO:0070062 [extracellular exosome]
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 473 aa
51.3 kDa 		No 0
KRT16-003
ENSP00000467124
ENST00000593067
K7ENW6 [Direct mapping]
Keratin, type I cytoskeletal 16
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
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 162 aa
18.6 kDa 		No 0
KRT16-004
ENSP00000467105
ENST00000590990
K7ENV3 [Direct mapping]
Keratin, type I cytoskeletal 16
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
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 49 aa
4.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.