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ERCC6L

GENERAL INFORMATION

Gene name

 ERCC6L

Gene description

 Excision repair cross-complementation group 6-like

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA050492
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050492

GENE INFORMATION

Gene name

 ERCC6L (HGNC Symbol)

Synonyms

 FLJ20105, PICH, RAD26L

Description

 Excision repair cross-complementation group 6-like (HGNC Symbol)

Entrez gene summary

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 72204657 - 72239047

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186871 (version 83.38)

Entrez gene

 54821

UniProt

 Q2NKX8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q2NKX8

Antibodypedia

 ERCC6L antibodies

PROTEIN BROWSER
ERCC6L-001
ERCC6L-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ERCC6L-001
ENSP00000362761
ENST00000373657
B5MDQ0 [Direct mapping]
DNA excision repair protein ERCC-6-like; FLJ20105 protein, isoform CRA_a
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
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 1127 aa
127 kDa 		No 0
ERCC6L-002
ENSP00000334675
ENST00000334463
Q2NKX8 [Direct mapping]
DNA excision repair protein ERCC-6-like
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000278 [mitotic cell cycle]
GO:0000777 [condensed chromosome kinetochore]
GO:0003677 [DNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0051301 [cell division]
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 1250 aa
141.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.