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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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FGF3
  • TISSUE

  • CELL

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

FGF3

Gene description

Fibroblast growth factor 3

Protein class

Cancer-related genes
Disease related genes
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (cervical cancer, endometrial cancer, head and neck cancer, lung cancer, ovarian cancer, stomach cancer, urothelial cancer)
HPA (cell line):Cell line enriched (CAPAN-2)
HPA (normal tissue):Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in cerebellum.

ANTIBODY IHC RELIABILITY

Data reliability
description

Presumed off target binding observed and disregarded. External characterization data supports antibody staining pattern while RNA data does not.

Reliability score

Uncertain based on 1 antibody.
HPA012692
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (cervical cancer, endometrial cancer, head and neck cancer, lung cancer, ovarian cancer, stomach cancer, urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA012692

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of malignant cells were negative or showed weak cytoplasmic and nuclear positivity. A few cases of colorectal, breast, ovarian and urothelial cancers were moderately stained. A single case of seminoma and a few cases of renal adenocarcinomas exhibited strong nuclear staining.

GENE INFORMATION

Gene name

FGF3 (HGNC Symbol)

Synonyms

HBGF-3, INT2

Description

Fibroblast growth factor 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.3

Chromosome location (bp)

69810224 - 69819024

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186895 (version 83.38)

Entrez gene

2248

UniProt

P11487 (UniProt - Evidence at protein level)

neXtProt

NX_P11487

Antibodypedia

FGF3 antibodies

PROTEIN BROWSER

FGF3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGF3-001
ENSP00000334122
ENST00000334134
P11487 [Direct mapping]
Fibroblast growth factor 3
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   Phobius predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
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GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001759 [organ induction]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0030916 [otic vesicle formation]
GO:0036342 [post-anal tail morphogenesis]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048538 [thymus development]
GO:0048752 [semicircular canal morphogenesis]
GO:0051781 [positive regulation of cell division]
GO:0055026 [negative regulation of cardiac muscle tissue development]
Show all
239 aa
26.9 kDa
Yes 0

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