Expression of FAM183A in cancer - Summary

GENERAL INFORMATION
Gene name	FAM183A
Gene description	Family with sequence similarity 183, member A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (endometrial cancer)
HPA (cell line):	Cell line enhanced (CAPAN-2, NTERA-2, SCLC-21H)
HPA (normal tissue):	Tissue enriched (fallopian tube)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in seminiferous ducts and ciliated cells of fallopian tube and bronchus.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA043382 , HPA049120
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043382	HPA049120

GENE INFORMATION
Gene name	FAM183A (HGNC Symbol)
Synonyms	hCG23177, LOC440585
Description	Family with sequence similarity 183, member A (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	43145153 - 43156396
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000186973 (version 83.38)
Entrez gene	440585
UniProt	A6NL82 (UniProt - Inferred from homology)
neXtProt	NX_A6NL82
Antibodypedia	FAM183A antibodies

PROTEIN BROWSER

FAM183A-001	FAM183A-003	FAM183A-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM183A-001 ENSP00000334415 ENST00000335282	A6NL82 [Direct mapping] Protein FAM183A Show all	Predicted intracellular proteins Show all		134 aa 16 kDa	No	0
FAM183A-003 ENSP00000387249 ENST00000410048	B7ZBL6 [Direct mapping] Protein FAM183A Show all	Predicted intracellular proteins Show all		106 aa 12.5 kDa	No	0
FAM183A-005 ENSP00000387254 ENST00000409396	B7ZBL7 [Direct mapping] Protein FAM183A Show all	Predicted intracellular proteins Show all		139 aa 16.3 kDa	No	0