Expression of ACTL7A in cancer - Summary - The Human Protein Atlas

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ACTL7A

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACTL7A
Gene description	Actin-like 7A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in spermatozoa.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA021624
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021624

GENE INFORMATION
Gene name	ACTL7A
Synonyms
Description	Actin-like 7A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q31.3
Chromosome location (bp)	108862266 - 108863759
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187003 (version 83.38)
Entrez gene	10881
UniProt	Q9Y615 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y615
Antibodypedia	ACTL7A antibodies

PROTEIN BROWSER

ACTL7A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACTL7A-001 ENSP00000334300 ENST00000333999	Q9Y615 [Direct mapping] Actin-like protein 7A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001673 [male germ cell nucleus] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005856 [cytoskeleton] GO:0031514 [motile cilium] GO:0043234 [protein complex] Show all	435 aa 48.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.