Expression of NAP1L1 in cancer - Summary

GENERAL INFORMATION
Gene name	NAP1L1
Gene description	Nucleosome assembly protein 1-like 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	19
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA028861
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA028861

GENE INFORMATION
Gene name	NAP1L1 (HGNC Symbol)
Synonyms	MGC23410, MGC8688, NAP1, NAP1L, NRP
Description	Nucleosome assembly protein 1-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]
Chromosome	12
Cytoband	q21.2
Chromosome location (bp)	76036587 - 76085033
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187109 (version 83.38)
Entrez gene	4673
UniProt	P55209 (UniProt - Evidence at protein level)
neXtProt	NX_P55209
Antibodypedia	NAP1L1 antibodies

PROTEIN BROWSER

NAP1L1-001	NAP1L1-004	NAP1L1-005	NAP1L1-006	NAP1L1-007	NAP1L1-008	NAP1L1-009	NAP1L1-010	NAP1L1-011	NAP1L1-012	NAP1L1-013	NAP1L1-016	NAP1L1-018	NAP1L1-020	NAP1L1-021	NAP1L1-022	NAP1L1-024	NAP1L1-027	NAP1L1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAP1L1-001 ENSP00000477538 ENST00000618691	P55209 [Direct mapping] Nucleosome assembly protein 1-like 1 A0A024RBB7 [Target identity:100%; Query identity:100%] Nucleosome assembly protein 1-like 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006334 [nucleosome assembly] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0042470 [melanosome] GO:0044822 [poly(A) RNA binding] Show all	391 aa 45.4 kDa	No	0
NAP1L1-004 ENSP00000409795 ENST00000431879	P55209 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006334 [nucleosome assembly] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0042470 [melanosome] GO:0044822 [poly(A) RNA binding] Show all	323 aa 37.3 kDa	No	0
NAP1L1-005 ENSP00000447793 ENST00000549596	P55209 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006334 [nucleosome assembly] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0042470 [melanosome] GO:0044822 [poly(A) RNA binding] Show all	368 aa 42.8 kDa	No	0
NAP1L1-006 ENSP00000437507 ENST00000544816	B7Z4K9 [Direct mapping] Nucleosome assembly protein 1-like 1; Nucleosome assembly protein 1-like 1, isoform CRA_e; cDNA FLJ59349, highly similar to Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	208 aa 23.9 kDa	No	0
NAP1L1-007 ENSP00000444759 ENST00000542344	B7Z9C2 [Direct mapping] Nucleosome assembly protein 1-like 1; cDNA FLJ58569, highly similar to Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	349 aa 40.5 kDa	No	0
NAP1L1-008 ENSP00000449649 ENST00000548044	F8VV59 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	327 aa 38 kDa	No	0
NAP1L1-009 ENSP00000448167 ENST00000547773	F8W543 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	328 aa 38.2 kDa	No	0
NAP1L1-010 ENSP00000376947 ENST00000393263	P55209 [Direct mapping] Nucleosome assembly protein 1-like 1 A0A024RBB7 [Target identity:100%; Query identity:100%] Nucleosome assembly protein 1-like 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006334 [nucleosome assembly] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0042470 [melanosome] GO:0044822 [poly(A) RNA binding] Show all	391 aa 45.4 kDa	No	0
NAP1L1-011 ENSP00000447196 ENST00000552342	F8W0J6 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	379 aa 43.9 kDa	No	0
NAP1L1-012 ENSP00000445008 ENST00000535020	F5H4R6 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	383 aa 44.6 kDa	No	0
NAP1L1-013 ENSP00000450236 ENST00000552056	H0YIV4 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	385 aa 44.7 kDa	No	0
NAP1L1-016 ENSP00000446787 ENST00000548273	F8W118 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	209 aa 24.7 kDa	No	0
NAP1L1-018 ENSP00000449333 ENST00000547479	F8VVB5 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	161 aa 18.8 kDa	No	0
NAP1L1-020 ENSP00000448133 ENST00000550934	F8VUX1 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	237 aa 27.7 kDa	No	0
NAP1L1-021 ENSP00000448836 ENST00000551600	F8VXI6 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	215 aa 25 kDa	No	0
NAP1L1-022 ENSP00000446756 ENST00000547704	F8W020 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	207 aa 24.4 kDa	No	0
NAP1L1-024 ENSP00000448764 ENST00000551992	F8VY35 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	264 aa 31 kDa	No	0
NAP1L1-027 ENSP00000448661 ENST00000551524	F8VRJ2 [Direct mapping] Nucleosome assembly protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006334 [nucleosome assembly] Show all	114 aa 13.5 kDa	No	0
NAP1L1-201 ENSP00000261182 ENST00000261182	P55209 [Direct mapping] Nucleosome assembly protein 1-like 1 A0A024RBB7 [Target identity:100%; Query identity:100%] Nucleosome assembly protein 1-like 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006334 [nucleosome assembly] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0042470 [melanosome] GO:0044822 [poly(A) RNA binding] Show all	391 aa 45.4 kDa	No	0