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AKR1C1

GENERAL INFORMATION

Gene name

 AKR1C1

Gene description

 Aldo-keto reductase family 1, member C1

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
CAB047303
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (unfavourable) and cervical cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB047303

GENE INFORMATION

Gene name

 AKR1C1 (HGNC Symbol)

Synonyms

 DD1, DDH, DDH1, HAKRC, MBAB

Description

 Aldo-keto reductase family 1, member C1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p15.1

Chromosome location (bp)

 4963253 - 5107522

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187134 (version 83.38)

Entrez gene

 1645

UniProt

 Q04828 (UniProt - Evidence at protein level)

neXtProt

 NX_Q04828

Antibodypedia

 AKR1C1 antibodies

PROTEIN BROWSER
AKR1C1-001
AKR1C1-003
AKR1C1-004
AKR1C1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKR1C1-001
ENSP00000370254
ENST00000380872
Q04828 [Direct mapping]
Aldo-keto reductase family 1 member C1
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001523 [retinoid metabolic process]
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0004033 [aldo-keto reductase (NADP) activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006805 [xenobiotic metabolic process]
GO:0007586 [digestion]
GO:0007603 [phototransduction, visible light]
GO:0008206 [bile acid metabolic process]
GO:0015721 [bile acid and bile salt transport]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0018636 [phenanthrene 9,10-monooxygenase activity]
GO:0030299 [intestinal cholesterol absorption]
GO:0030855 [epithelial cell differentiation]
GO:0031406 [carboxylic acid binding]
GO:0032052 [bile acid binding]
GO:0042448 [progesterone metabolic process]
GO:0042574 [retinal metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0046683 [response to organophosphorus]
GO:0047006 [17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity]
GO:0047042 [androsterone dehydrogenase (B-specific) activity]
GO:0047086 [ketosteroid monooxygenase activity]
GO:0047115 [trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity]
GO:0047718 [indanol dehydrogenase activity]
GO:0051260 [protein homooligomerization]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071395 [cellular response to jasmonic acid stimulus]
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 323 aa
36.8 kDa 		No 0
AKR1C1-003
ENSP00000416415
ENST00000442997
H0Y804 [Direct mapping]
Aldo-keto reductase family 1 member C1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 248 aa
28.1 kDa 		No 0
AKR1C1-004
ENSP00000370240
ENST00000380859
A6NHU4 [Direct mapping]
Aldo-keto reductase family 1 member C1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 205 aa
23.2 kDa 		Yes 0
AKR1C1-201
ENSP00000412248
ENST00000434459
A0A0A0MT30 [Direct mapping]
Aldo-keto reductase family 1 member C1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 324 aa
37.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.