Expression of KRT12 in cancer - Summary - The Human Protein Atlas

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KRT12

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KRT12
Gene description	Keratin 12, type I
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly expressed in the cornea.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining but no internal RNA data available for correlation. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA055217 , HPA055835
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055217	HPA055835

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Cancer tissues were negative in general.

GENE INFORMATION
Gene name	KRT12 (HGNC Symbol)
Synonyms	K12
Description	Keratin 12, type I (HGNC Symbol)
Entrez gene summary	KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	40861303 - 40867210
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187242 (version 83.38)
Entrez gene	3859
UniProt	Q99456 (UniProt - Evidence at protein level)
neXtProt	NX_Q99456
Antibodypedia	KRT12 antibodies

PROTEIN BROWSER

KRT12-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT12-001 ENSP00000251643 ENST00000251643	Q99456 [Direct mapping] Keratin, type I cytoskeletal 12 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] GO:0007601 [visual perception] GO:0060429 [epithelium development] GO:0061303 [cornea development in camera-type eye] GO:0070062 [extracellular exosome] Show all	494 aa 53.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.