Expression of NPSR1 in cancer - Summary - The Human Protein Atlas

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NPSR1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NPSR1
Gene description	Neuropeptide S receptor 1
Protein class	Disease related genes G-protein coupled receptors Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (stomach cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in neuroendocrine cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA007489
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007489

GENE INFORMATION
Gene name	NPSR1 (HGNC Symbol)
Synonyms	GPR154, GPRA, PGR14
Description	Neuropeptide S receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	7
Cytoband	p14.3
Chromosome location (bp)	34658239 - 34878332
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187258 (version 83.38)
Entrez gene	387129
UniProt	Q6W5P4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6W5P4
Antibodypedia	NPSR1 antibodies

PROTEIN BROWSER

NPSR1-001	NPSR1-002	NPSR1-004	NPSR1-006	NPSR1-007	NPSR1-008	NPSR1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPSR1-001 ENSP00000353788 ENST00000360581	Q6W5P4 [Direct mapping] Neuropeptide S receptor A0A090N8Z1 [Target identity:100%; Query identity:100%] G protein-coupled receptor 154; G protein-coupled receptor 154, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005000 [vasopressin receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008188 [neuropeptide receptor activity] GO:0016021 [integral component of membrane] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] Show all	371 aa 42.7 kDa	No	7
NPSR1-002 ENSP00000352839 ENST00000359791	Q6W5P4 [Direct mapping] Neuropeptide S receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005000 [vasopressin receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008188 [neuropeptide receptor activity] GO:0016021 [integral component of membrane] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] Show all	377 aa 43.1 kDa	No	7
NPSR1-004 ENSP00000370953 ENST00000381542	Q6W5P4 [Direct mapping] Neuropeptide S receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005000 [vasopressin receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008188 [neuropeptide receptor activity] GO:0016021 [integral component of membrane] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] Show all	305 aa 35.1 kDa	No	5
NPSR1-006 ENSP00000370965 ENST00000381553	Q6W5P4 [Direct mapping] Neuropeptide S receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005000 [vasopressin receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008188 [neuropeptide receptor activity] GO:0016021 [integral component of membrane] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] Show all	143 aa 16.4 kDa	No	2
NPSR1-007 ENSP00000370950 ENST00000381539	Q6W5P4 [Direct mapping] Neuropeptide S receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005000 [vasopressin receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008188 [neuropeptide receptor activity] GO:0016021 [integral component of membrane] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] Show all	390 aa 44.3 kDa	No	7
NPSR1-008 ENSP00000434955 ENST00000465305	Q6W5P4 [Direct mapping] Neuropeptide S receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005000 [vasopressin receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007218 [neuropeptide signaling pathway] GO:0008188 [neuropeptide receptor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] Show all	94 aa 10.6 kDa	No	1
NPSR1-009 ENSP00000433258 ENST00000531252	Q6W5P4 [Direct mapping] Neuropeptide S receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005000 [vasopressin receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008188 [neuropeptide receptor activity] GO:0016021 [integral component of membrane] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] Show all	366 aa 42 kDa	No	7

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