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EPOR

GENERAL INFORMATION

Gene name

 EPOR

Gene description

 Erythropoietin receptor

Protein class

 Cancer-related genes
Disease related genes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 EPOR

Synonyms

Description

 Erythropoietin receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 11377205 - 11384342

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187266 (version 83.38)

Entrez gene

 2057

UniProt

 P19235 (UniProt - Evidence at protein level)

neXtProt

 NX_P19235

Antibodypedia

 EPOR antibodies

PROTEIN BROWSER
EPOR-001
EPOR-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPOR-001
ENSP00000222139
ENST00000222139
P19235 [Direct mapping]
Erythropoietin receptor
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004896 [cytokine receptor activity]
GO:0004900 [erythropoietin receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0008284 [positive regulation of cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0038162 [erythropoietin-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0046697 [decidualization]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
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 508 aa
55.1 kDa 		Yes 1
EPOR-005
ENSP00000467809
ENST00000592375
P19235 [Direct mapping]
Erythropoietin receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Show all
GO:0004896 [cytokine receptor activity]
GO:0004900 [erythropoietin receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005887 [integral component of plasma membrane]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0038162 [erythropoietin-mediated signaling pathway]
GO:0042802 [identical protein binding]
Show all
 328 aa
35.8 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.