Tissue expression of CIDEC - Summary - The Human Protein Atlas

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CIDEC

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CIDEC
Gene description	Cell death-inducing DFFA-like effector c
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (adipose tissue)
GTEx:	Group enriched (adipose tissue, breast)
FANTOM5:	Group enriched (adipose tissue, breast, colon, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues with extracellular positivity, including adipocytes.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA018837 , HPA020553
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (adipose tissue)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (adipose tissue, breast)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (adipose tissue, breast, colon, small intestine)

GENE INFORMATION
Gene name	CIDEC (HGNC Symbol)
Synonyms	CIDE-3, FLJ20871, Fsp27
Description	Cell death-inducing DFFA-like effector c (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	9866711 - 9880254
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187288 (version 83.38)
Entrez gene	63924
UniProt	Q96AQ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96AQ7
Antibodypedia	CIDEC antibodies

PROTEIN BROWSER

CIDEC-001	CIDEC-002	CIDEC-003	CIDEC-004	CIDEC-006	CIDEC-201	CIDEC-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CIDEC-001 ENSP00000338642 ENST00000336832	Q96AQ7 [Direct mapping] Cell death activator CIDE-3 A0A024R2F7 [Target identity:100%; Query identity:100%] Cell death-inducing DFFA-like effector c, isoform CRA_a Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0003674 [molecular_function] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0034389 [lipid particle organization] GO:0042981 [regulation of apoptotic process] GO:0097194 [execution phase of apoptosis] Show all	238 aa 26.8 kDa	No	0
CIDEC-002 ENSP00000392975 ENST00000455015	Q96AQ7 [Direct mapping] Cell death activator CIDE-3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0003674 [molecular_function] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0034389 [lipid particle organization] GO:0042981 [regulation of apoptotic process] GO:0097194 [execution phase of apoptosis] Show all	164 aa 18.4 kDa	No	0
CIDEC-003 ENSP00000400649 ENST00000423850	Q96AQ7 [Direct mapping] Cell death activator CIDE-3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0003674 [molecular_function] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0034389 [lipid particle organization] GO:0042981 [regulation of apoptotic process] GO:0097194 [execution phase of apoptosis] Show all	164 aa 18.4 kDa	No	0
CIDEC-004 ENSP00000411356 ENST00000443115	A0A0C4DG75 [Direct mapping] Cell death activator CIDE-3 Show all	Predicted intracellular proteins Show all	GO:0005622 [intracellular] GO:0005811 [lipid particle] GO:0006915 [apoptotic process] GO:0042981 [regulation of apoptotic process] Show all	133 aa 14.5 kDa	No	0
CIDEC-006 ENSP00000408631 ENST00000430427	Q96AQ7 [Direct mapping] Cell death activator CIDE-3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0003674 [molecular_function] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0034389 [lipid particle organization] GO:0042981 [regulation of apoptotic process] GO:0097194 [execution phase of apoptosis] Show all	248 aa 27.9 kDa	No	0
CIDEC-201 ENSP00000373328 ENST00000383817	A0A0A0MRY9 [Direct mapping] Cell death activator CIDE-3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005622 [intracellular] GO:0005811 [lipid particle] GO:0006915 [apoptotic process] GO:0042981 [regulation of apoptotic process] Show all	251 aa 28.3 kDa	No	0
CIDEC-202 ENSP00000483641 ENST00000618572	Q96AQ7 [Direct mapping] Cell death activator CIDE-3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0003674 [molecular_function] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0034389 [lipid particle organization] GO:0042981 [regulation of apoptotic process] GO:0097194 [execution phase of apoptosis] Show all	248 aa 27.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.