Expression of DCC in cancer - Summary - The Human Protein Atlas

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DCC

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DCC
Gene description	DCC netrin 1 receptor
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (AF22, U-266/70, U-266/84)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in CNS and in gastric glands of stomach.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Supported based on 1 antibody. HPA069552
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA069552

GENE INFORMATION
Gene name	DCC (HGNC Symbol)
Synonyms	IGDCC1, NTN1R1
Description	DCC netrin 1 receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
Chromosome	18
Cytoband	q21.2
Chromosome location (bp)	52340172 - 53535903
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187323 (version 83.38)
Entrez gene	1630
UniProt	P43146 (UniProt - Evidence at protein level)
neXtProt	NX_P43146
Antibodypedia	DCC antibodies

PROTEIN BROWSER

DCC-001	DCC-004	DCC-007	DCC-011	DCC-012	DCC-015	DCC-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCC-001 ENSP00000389140 ENST00000442544	P43146 [Direct mapping] Netrin receptor DCC Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0010977 [negative regulation of neuron projection development] GO:0012501 [programmed cell death] GO:0016021 [integral component of membrane] GO:0021965 [spinal cord ventral commissure morphogenesis] GO:0030424 [axon] GO:0033563 [dorsal/ventral axon guidance] GO:0033564 [anterior/posterior axon guidance] GO:0048671 [negative regulation of collateral sprouting] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1901214 [regulation of neuron death] GO:2000171 [negative regulation of dendrite development] Show all	1447 aa 158.5 kDa	Yes	1
DCC-004 ENSP00000463699 ENST00000578080	J3QLT8 [Direct mapping] Netrin receptor DCC Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	181 aa 20.1 kDa	No	0
DCC-007 ENSP00000463131 ENST00000582875	J3QKL2 [Direct mapping] Netrin receptor DCC Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	88 aa 9.7 kDa	No	0
DCC-011 ENSP00000464582 ENST00000581580	J3QS93 [Direct mapping] Netrin receptor DCC Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1076 aa 117.9 kDa	No	1
DCC-012 ENSP00000463766 ENST00000578949	J3QQJ6 [Direct mapping] Netrin receptor DCC Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	102 aa 10.9 kDa	No	0
DCC-015 ENSP00000464292 ENST00000579941	J3QRM6 [Direct mapping] Netrin receptor DCC Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	208 aa 23.4 kDa	No	0
DCC-201 ENSP00000397322 ENST00000412726	E7EQM8 [Direct mapping] Netrin receptor DCC Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1424 aa 155.8 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.