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SIRT7

GENERAL INFORMATION

Gene name

 SIRT7

Gene description

 Sirtuin 7

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear and nucleolar expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA053669 , CAB037261
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA053669
CAB037261

GENE INFORMATION

Gene name

 SIRT7

Synonyms

Description

 Sirtuin 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 81911939 - 81921323

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187531 (version 83.38)

Entrez gene

 51547

UniProt

 Q9NRC8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRC8

Antibodypedia

 SIRT7 antibodies

PROTEIN BROWSER
SIRT7-001
SIRT7-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIRT7-001
ENSP00000329466
ENST00000328666
Q9NRC8 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-7
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005731 [nucleolus organizer region]
GO:0005737 [cytoplasm]
GO:0007072 [positive regulation of transcription involved in exit from mitosis]
GO:0009303 [rRNA transcription]
GO:0046872 [metal ion binding]
GO:0070403 [NAD+ binding]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0097372 [NAD-dependent histone deacetylase activity (H3-K18 specific)]
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 400 aa
44.9 kDa 		No 0
SIRT7-008
ENSP00000461044
ENST00000572902
I3L480 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0070403 [NAD+ binding]
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 150 aa
17.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.