Expression of PRR27 in cancer - Summary - The Human Protein Atlas

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PRR27

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRR27
Gene description	Proline rich 27
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (breast cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in salivary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA036150 , HPA036151
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (breast cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036150	HPA036151

GENE INFORMATION
Gene name	PRR27 (HGNC Symbol)
Synonyms	C4orf40
Description	Proline rich 27 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	70133616 - 70176799
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187533 (version 83.38)
Entrez gene	401137
UniProt	Q6MZM9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6MZM9
Antibodypedia	PRR27 antibodies

PROTEIN BROWSER

PRR27-001	PRR27-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRR27-001 ENSP00000343172 ENST00000344526	Q6MZM9 [Direct mapping] Proline-rich protein 27 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0070062 [extracellular exosome] Show all	219 aa 22.7 kDa	Yes	0
PRR27-002 ENSP00000426249 ENST00000502294	Q6MZM9 [Direct mapping] Proline-rich protein 27 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0070062 [extracellular exosome] Show all	219 aa 22.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.