Expression of AGMO in cancer - Summary - The Human Protein Atlas

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AGMO

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	AGMO
Gene description	Alkylglycerol monooxygenase
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enhanced (Karpas-707, WM-115)
HPA (normal tissue):	Tissue enhanced (liver)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	AGMO (HGNC Symbol)
Synonyms	FLJ16237, TMEM195
Description	Alkylglycerol monooxygenase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent enzymes. Variations in this gene have been associated with decreased glucose-stimulated insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms. [provided by RefSeq, Aug 2012]
Chromosome	7
Cytoband	p21.2
Chromosome location (bp)	15200318 - 15562015
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187546 (version 83.38)
Entrez gene	392636
UniProt	Q6ZNB7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZNB7
Antibodypedia	AGMO antibodies

PROTEIN BROWSER

AGMO-001	AGMO-003	AGMO-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGMO-001 ENSP00000341662 ENST00000342526	Q6ZNB7 [Direct mapping] Alkylglycerol monooxygenase X5D773 [Target identity:100%; Query identity:100%] Alkylglycerol monooxygenase isoform A Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006633 [fatty acid biosynthetic process] GO:0006643 [membrane lipid metabolic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0019432 [triglyceride biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046485 [ether lipid metabolic process] GO:0050479 [glyceryl-ether monooxygenase activity] GO:0055114 [oxidation-reduction process] Show all	445 aa 51.5 kDa	No	8
AGMO-003 ENSP00000394412 ENST00000418075	H7C0E0 [Direct mapping] Alkylglycerol monooxygenase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	74 aa 8.3 kDa	No	2
AGMO-004 ENSP00000385742 ENST00000407277	H0Y3V1 [Direct mapping] Alkylglycerol monooxygenase Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		87 aa 9.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.