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SBK2

GENERAL INFORMATION

Gene name

 SBK2

Gene description

 SH3 domain binding kinase family, member 2

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (ovarian cancer)
HPA (cell line):Cell line enhanced (A549, MCF7, NTERA-2, RH-30, U-2 OS)
HPA (normal tissue):Tissue enriched (heart muscle)

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Cytoplasmic expression in cardiac myocytes and subset of renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA030631
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (ovarian cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA030631

GENE INFORMATION

Gene name

 SBK2 (HGNC Symbol)

Synonyms

 SGK069

Description

 SH3 domain binding kinase family, member 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 q13.42

Chromosome location (bp)

 55529733 - 55537089

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000187550 (version 83.38)

Entrez gene

 646643

UniProt

 P0C263 (UniProt - Inferred from homology)

neXtProt

 NX_P0C263

Antibodypedia

 SBK2 antibodies

PROTEIN BROWSER
SBK2-001
SBK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SBK2-001
ENSP00000389015
ENST00000413299
P0C263 [Direct mapping]
Serine/threonine-protein kinase SBK2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
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 348 aa
38.1 kDa 		No 1
SBK2-201
ENSP00000345044
ENST00000344158
P0C263 [Direct mapping]
Serine/threonine-protein kinase SBK2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 348 aa
38.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.