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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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FOXD4L3
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

FOXD4L3

Gene description

Forkhead box D4-like 3

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification. Caution, targets protein from more than one gene.

Reliability score

Uncertain based on 1 antibody.
HPA012836
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA012836

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Most malignant cells exhibited weak to moderate nuclear immunoreactivity, occasionally combined with cytoplasmic positivity. Malignant lymphomas were strongly stained.

GENE INFORMATION

Gene name

FOXD4L3 (HGNC Symbol)

Synonyms

FOXD6

Description

Forkhead box D4-like 3 (HGNC Symbol)

Entrez gene summary

Chromosome

9

Cytoband

q21.11

Chromosome location (bp)

68302867 - 68304905

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000187559 (version 83.38)

Entrez gene

286380

UniProt

Q6VB84 (UniProt - Evidence at transcript level)

neXtProt

NX_Q6VB84

Antibodypedia

FOXD4L3 antibodies

PROTEIN BROWSER

FOXD4L3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FOXD4L3-001
ENSP00000341961
ENST00000342833
Q6VB84 [Direct mapping]
Forkhead box protein D4-like 3
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
417 aa
45.8 kDa
No 0

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