Expression of PLEKHN1 in cancer - Summary - The Human Protein Atlas

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PLEKHN1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PLEKHN1
Gene description	Pleckstrin homology domain containing, family N member 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HaCaT)
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification. Subcellular localisation is contradicted by limited external data.
Reliability score	Uncertain based on 1 antibody. HPA031742
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031742

GENE INFORMATION
Gene name	PLEKHN1 (HGNC Symbol)
Synonyms	DKFZP434H2010
Description	Pleckstrin homology domain containing, family N member 1 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	966497 - 975865
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187583 (version 83.38)
Entrez gene	84069
UniProt	Q494U1 (UniProt - Evidence at protein level)
neXtProt	NX_Q494U1
Antibodypedia	PLEKHN1 antibodies

PROTEIN BROWSER

PLEKHN1-001	PLEKHN1-003	PLEKHN1-004	PLEKHN1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLEKHN1-001 ENSP00000368720 ENST00000379410	Q494U1 [Direct mapping] Pleckstrin homology domain-containing family N member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] Show all	611 aa 66.4 kDa	No	0
PLEKHN1-003 ENSP00000462558 ENST00000491024	J3KSM5 [Direct mapping] Pleckstrin homology domain-containing family N member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		176 aa 18.6 kDa	No	0
PLEKHN1-004 ENSP00000368717 ENST00000379407	Q494U1 [Direct mapping] Pleckstrin homology domain-containing family N member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] Show all	576 aa 62.6 kDa	No	0
PLEKHN1-005 ENSP00000368719 ENST00000379409	Q494U1 [Direct mapping] Pleckstrin homology domain-containing family N member 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] Show all	663 aa 71.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.