Cell atlas - DHRS4L2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DHRS4L2
Gene description	Dehydrogenase/reductase (SDR family) member 4 like 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the nuclear membrane. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (uncertain)
Additional location	In addition localized to the Nuclear membrane (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA023972
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the nuclear membrane. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Vesicles (uncertain)

Additional location

Nuclear membrane (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA023972	A-431	Nuclear membrane
HPA023972	A-431	Vesicles
HPA023972	U-2 OS	Vesicles
HPA023972	U-251 MG	No staining

GENE INFORMATION
Gene name	DHRS4L2 (HGNC Symbol)
Synonyms	SDR25C3
Description	Dehydrogenase/reductase (SDR family) member 4 like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	23969874 - 24006408
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187630 (version 83.38)
Entrez gene	317749
UniProt	Q6PKH6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6PKH6
Antibodypedia	DHRS4L2 antibodies

PROTEIN BROWSER

DHRS4L2-001	DHRS4L2-003	DHRS4L2-004	DHRS4L2-005	DHRS4L2-006	DHRS4L2-008	DHRS4L2-009	DHRS4L2-201	DHRS4L2-202	DHRS4L2-203	DHRS4L2-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHRS4L2-001 ENSP00000334801 ENST00000335125	Q6PKH6 [Direct mapping] Dehydrogenase/reductase SDR family member 4-like 2 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	232 aa 24.9 kDa	Yes	0
DHRS4L2-003 ENSP00000380261 ENST00000397071	E9PFL3 [Direct mapping] Dehydrogenase/reductase SDR family member 4-like 2 Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	192 aa 20.9 kDa	No	0
DHRS4L2-004 ENSP00000453889 ENST00000559411	H0YN69 [Direct mapping] Dehydrogenase/reductase SDR family member 4-like 2 Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	242 aa 25.8 kDa	No	0
DHRS4L2-005 ENSP00000439942 ENST00000537912	F6TD35 [Direct mapping] Dehydrogenase/reductase SDR family member 4-like 2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	157 aa 17.1 kDa	No	0
DHRS4L2-006 ENSP00000453845 ENST00000558753	F6TD35 [Direct mapping] Dehydrogenase/reductase SDR family member 4-like 2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	157 aa 17.1 kDa	No	0
DHRS4L2-008 ENSP00000453173 ENST00000559387	H0YLE1 [Direct mapping] Dehydrogenase/reductase SDR family member 4-like 2 Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	49 aa 5.2 kDa	No	0
DHRS4L2-009 ENSP00000452875 ENST00000560276	H0YKN3 [Direct mapping] Dehydrogenase/reductase SDR family member 4-like 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	109 aa 11.6 kDa	No	0
DHRS4L2-201 ENSP00000372203 ENST00000382755	D3YTE6 [Direct mapping] Dehydrogenase/reductase SDR family member 4-like 2 Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	276 aa 29.7 kDa	No	0
DHRS4L2-202 ENSP00000441095 ENST00000534993	F6VUV4 [Direct mapping] Dehydrogenase/reductase SDR family member 4-like 2 Show all	Predicted intracellular proteins Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	90 aa 9.8 kDa	No	0
DHRS4L2-203 ENSP00000441433 ENST00000543805	A0A087WSZ6 [Direct mapping] Dehydrogenase/reductase SDR family member 4-like 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	138 aa 15 kDa	No	0
DHRS4L2-204 ENSP00000481066 ENST00000621761	A0A087WXI8 [Direct mapping] Dehydrogenase/reductase SDR family member 4-like 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	215 aa 23.2 kDa	No	0