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Granular cytoplasmic staining in most malignancies at variable levels, highest expression in liver cancers. Most skin cancers were negative.
GENE INFORMATION
Gene name
SPRY4
Synonyms
Description
Sprouty RTK signaling antagonist 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014]