Expression of TRPV2 in cancer - Summary - The Human Protein Atlas

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TRPV2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TRPV2
Gene description	Transient receptor potential cation channel, subfamily V, member 2
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (melanoma)
HPA (cell line):	Cell line enhanced (HMC-1, SK-MEL-30, TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044993
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and testis cancer (unfavourable).
Renal cancer p<0.001 Testis cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044993

GENE INFORMATION
Gene name	TRPV2 (HGNC Symbol)
Synonyms	VRL, VRL-1, VRL1
Description	Transient receptor potential cation channel, subfamily V, member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	16415542 - 16437003
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187688 (version 83.38)
Entrez gene	51393
UniProt	Q9Y5S1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5S1
Antibodypedia	TRPV2 antibodies

PROTEIN BROWSER

TRPV2-001	TRPV2-006	TRPV2-007	TRPV2-009	TRPV2-010	TRPV2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPV2-001 ENSP00000342222 ENST00000338560	Q9Y5S1 [Direct mapping] Transient receptor potential cation channel subfamily V member 2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005261 [cation channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007600 [sensory perception] GO:0008285 [negative regulation of cell proliferation] GO:0009266 [response to temperature stimulus] GO:0009408 [response to heat] GO:0009986 [cell surface] GO:0015075 [ion transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030027 [lamellipodium] GO:0030424 [axon] GO:0032584 [growth cone membrane] GO:0034220 [ion transmembrane transport] GO:0042470 [melanosome] GO:0044295 [axonal growth cone] GO:0044297 [cell body] GO:0045773 [positive regulation of axon extension] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0090280 [positive regulation of calcium ion import] Show all	764 aa 86 kDa	No	6
TRPV2-006 ENSP00000390014 ENST00000455666	H7BZK2 [Direct mapping] Transient receptor potential cation channel subfamily V member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0009408 [response to heat] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	266 aa 29 kDa	No	0
TRPV2-007 ENSP00000464850 ENST00000577277	K7EIQ6 [Direct mapping] Transient receptor potential cation channel subfamily V member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0009408 [response to heat] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	77 aa 8.4 kDa	No	1
TRPV2-009 ENSP00000465609 ENST00000581560	K7EKG5 [Direct mapping] Transient receptor potential cation channel subfamily V member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0009408 [response to heat] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	138 aa 15.6 kDa	No	1
TRPV2-010 ENSP00000466130 ENST00000580788	K7ELL3 [Direct mapping] Transient receptor potential cation channel subfamily V member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0009408 [response to heat] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	96 aa 10.4 kDa	No	1
TRPV2-011 ENSP00000467593 ENST00000577865	K7EPY7 [Direct mapping] Transient receptor potential cation channel subfamily V member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0009408 [response to heat] GO:0070588 [calcium ion transmembrane transport] Show all	90 aa 9.9 kDa	No	0

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The Human Protein Atlas

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