Expression of AMY1C in cancer - Summary - The Human Protein Atlas

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AMY1C

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AMY1C
Gene description	Amylase, alpha 1C (salivary)
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (cervix, uterine, salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in salivary gland and exocrine pancreas.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 3 antibodies. HPA045394 , HPA045399 , HPA046980
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA045394	HPA045399	HPA046980

GENE INFORMATION
Gene name	AMY1C (HGNC Symbol)
Synonyms	AMY1
Description	Amylase, alpha 1C (salivary) (HGNC Symbol)
Entrez gene summary	Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p21.1
Chromosome location (bp)	103750406 - 103758690
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187733 (version 83.38)
Entrez gene	278
UniProt	P04745 (UniProt - Evidence at protein level)
neXtProt	NX_P04745
Antibodypedia	AMY1C antibodies

PROTEIN BROWSER

AMY1C-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMY1C-001 ENSP00000359096 ENST00000370079	P04745 [Direct mapping] Alpha-amylase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003824 [catalytic activity] GO:0004556 [alpha-amylase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0007586 [digestion] GO:0043169 [cation binding] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	511 aa 57.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.