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TCEA1

GENERAL INFORMATION

Gene name

 TCEA1

Gene description

 Transcription elongation factor A (SII), 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA043786
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043786

GENE INFORMATION

Gene name

 TCEA1 (HGNC Symbol)

Synonyms

 GTF2S, SII, TCEA, TF2S, TFIIS

Description

 Transcription elongation factor A (SII), 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 8

Cytoband

 q11.23

Chromosome location (bp)

 53966552 - 54022529

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187735 (version 83.38)

Entrez gene

 6917

UniProt

 P23193 (UniProt - Evidence at protein level)

neXtProt

 NX_P23193

Antibodypedia

 TCEA1 antibodies

PROTEIN BROWSER
TCEA1-002
TCEA1-003
TCEA1-010
TCEA1-011
TCEA1-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TCEA1-002
ENSP00000428426
ENST00000521604
P23193 [Direct mapping]
Transcription elongation factor A protein 1
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0030218 [erythrocyte differentiation]
GO:0032784 [regulation of DNA-templated transcription, elongation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050434 [positive regulation of viral transcription]
GO:1901919 [positive regulation of exoribonuclease activity]
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 301 aa
34 kDa 		No 0
TCEA1-003
ENSP00000429192
ENST00000522635
B7Z4S1 [Direct mapping]
Transcription elongation factor A protein 1; cDNA FLJ51251, moderately similar to Transcription elongation factor A protein 1
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003746 [translation elongation factor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006414 [translational elongation]
GO:0008270 [zinc ion binding]
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 117 aa
13.4 kDa 		No 0
TCEA1-010
ENSP00000429182
ENST00000518784
E5RJ93 [Direct mapping]
Transcription elongation factor A protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 90 aa
10.2 kDa 		No 0
TCEA1-011
ENSP00000428370
ENST00000520534
E5RIS7 [Direct mapping]
Transcription elongation factor A protein 1
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 111 aa
12.6 kDa 		No 0
TCEA1-013
ENSP00000395483
ENST00000396401
P23193 [Direct mapping]
Transcription elongation factor A protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032784 [regulation of DNA-templated transcription, elongation]
GO:0050434 [positive regulation of viral transcription]
Show all
 280 aa
31.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.