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ADH1A

GENERAL INFORMATION

Gene name

 ADH1A

Gene description

 Alcohol dehydrogenase 1A (class I), alpha polypeptide

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (ASC TERT1)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in hepatocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA047814 , HPA060902 , CAB009562
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047814
HPA060902
CAB009562

GENE INFORMATION

Gene name

 ADH1A (HGNC Symbol)

Synonyms

 ADH1

Description

 Alcohol dehydrogenase 1A (class I), alpha polypeptide (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]

Chromosome

 4

Cytoband

 q23

Chromosome location (bp)

 99276367 - 99291028

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187758 (version 83.38)

Entrez gene

 124

UniProt

 P07327 (UniProt - Evidence at protein level)

neXtProt

 NX_P07327

Antibodypedia

 ADH1A antibodies

PROTEIN BROWSER
ADH1A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADH1A-001
ENSP00000209668
ENST00000209668
P07327 [Direct mapping]
Alcohol dehydrogenase 1A
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006066 [alcohol metabolic process]
GO:0006069 [ethanol oxidation]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0017144 [drug metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 375 aa
39.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.