Moderate to strong cytoplasmic and nuclear staining was observed in liver cancers. Several cases of lymphomas along with a few ovarian, colorectal, breast and prostate cancers showed weak to moderate staining. Remaining cancer tissues were mainly negative.
Several cases of hepatocellular carcinomas along with few cases of cervix cancers showed moderate cytoplasmic and nuclear staining. Few cases of stomach cancers displayed moderate cytoplasmic positivity. Remaining cancer tissues were negative.
This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)