Expression of FAM69C in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

FAM69C

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM69C
Gene description	Family with sequence similarity 69, member C
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, melanoma)
HPA (cell line):	Cell line enriched (SK-MEL-30)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in neuronal cells, spermatids and spermatocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA048928
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048928

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most cancer cells were negative. Rare cases of gliomas, liver and prostate cancers showed moderate cytoplasmic positivity.

GENE INFORMATION
Gene name	FAM69C (HGNC Symbol)
Synonyms	C18orf51
Description	Family with sequence similarity 69, member C (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. [provided by RefSeq, Nov 2011]
Chromosome	18
Cytoband	q22.3
Chromosome location (bp)	74434099 - 74457944
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187773 (version 83.38)
Entrez gene	125704
UniProt	Q0P6D2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q0P6D2
Antibodypedia	FAM69C antibodies

PROTEIN BROWSER

FAM69C-001	FAM69C-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM69C-001 ENSP00000344331 ENST00000343998	Q0P6D2 [Direct mapping] Protein FAM69C Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	419 aa 46.4 kDa	No	0
FAM69C-002 ENSP00000383148 ENST00000400291	Q0P6D2 [Direct mapping] Protein FAM69C Show all	Predicted intracellular proteins Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	120 aa 13.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.