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HIST1H1C

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GENERAL INFORMATION

Gene name

 HIST1H1C

Gene description

 Histone cluster 1, H1c

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & nucleoli.

RNA cell category

 Cell line enhanced (U-2 OS, U-266/70, U-266/84)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Nucleoli (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB011507
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2 OS, U-266/70, U-266/84)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & nucleoli.

Main location

 Nucleus (supported), Nucleoli (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB011507 A-431 Nucleus
Nucleoli
CAB011507 U-2 OS Nucleus
Nucleoli
CAB011507 U-251 MG Nucleus
Nucleoli Intensity

GENE INFORMATION

Gene name

 HIST1H1C (HGNC Symbol)

Synonyms

 H1.2, H1c, H1F2, H1s-1

Description

 Histone cluster 1, H1c (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

Chromosome

 6

Cytoband

 p22.2

Chromosome location (bp)

 26055787 - 26056428

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187837 (version 83.38)

Entrez gene

 3006

UniProt

 P16403 (UniProt - Evidence at protein level)

neXtProt

 NX_P16403

Antibodypedia

 HIST1H1C antibodies

PROTEIN BROWSER
HIST1H1C-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIST1H1C-001
ENSP00000339566
ENST00000343677
P16403 [Direct mapping]
Histone H1.2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005719 [nuclear euchromatin]
GO:0006334 [nucleosome assembly]
GO:0016584 [nucleosome positioning]
GO:0031490 [chromatin DNA binding]
GO:0035327 [transcriptionally active chromatin]
GO:0044822 [poly(A) RNA binding]
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 213 aa
21.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.