Expression of ASCL4 in cancer - Summary - The Human Protein Atlas

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ASCL4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASCL4
Gene description	Achaete-scute family bHLH transcription factor 4
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (melanoma)
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA036116
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036116

GENE INFORMATION
Gene name	ASCL4 (HGNC Symbol)
Synonyms	bHLHa44, HASH4
Description	Achaete-scute family bHLH transcription factor 4 (HGNC Symbol)
Entrez gene summary	Basic helix-loop-helix transcription factors, such as ASCL4, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q23.3
Chromosome location (bp)	107774385 - 107776644
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187855 (version 83.38)
Entrez gene	121549
UniProt	Q6XD76 (UniProt - Evidence at protein level)
neXtProt	NX_Q6XD76
Antibodypedia	ASCL4 antibodies

PROTEIN BROWSER

ASCL4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASCL4-001 ENSP00000345420 ENST00000342331	Q6XD76 [Direct mapping] Achaete-scute homolog 4 Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043588 [skin development] GO:0046983 [protein dimerization activity] Show all	173 aa 19.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.