Expression of PALM3 in cancer - Summary - The Human Protein Atlas

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PALM3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PALM3
Gene description	Paralemmin 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AN3-CA, CACO-2, NTERA-2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression mainly in stomach, kidney, parathyroid gland and epididymis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Nuclear staining observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA052794 , HPA056119
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052794	HPA056119

GENE INFORMATION
Gene name	PALM3
Synonyms
Description	Paralemmin 3 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.12
Chromosome location (bp)	14053365 - 14059159
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187867 (version 83.38)
Entrez gene	342979
UniProt	A6NDB9 (UniProt - Evidence at protein level)
neXtProt	NX_A6NDB9
Antibodypedia	PALM3 antibodies

PROTEIN BROWSER

PALM3-001	PALM3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PALM3-001 ENSP00000344996 ENST00000340790	A6NDB9 [Direct mapping] Paralemmin-3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001960 [negative regulation of cytokine-mediated signaling pathway] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008063 [Toll signaling pathway] GO:0032496 [response to lipopolysaccharide] Show all	673 aa 71.7 kDa	No	0
PALM3-002 ENSP00000465701 ENST00000589048	K7EKN5 [Direct mapping] Paralemmin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		193 aa 19.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.