Expression of S100A3 in cancer - Summary

GENERAL INFORMATION
Gene name	S100A3
Gene description	S100 calcium binding protein A3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in cells of the hair cuticle layer. Also expressed in other tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA042674
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA042674

GENE INFORMATION
Gene name	S100A3 (HGNC Symbol)
Synonyms	S100E
Description	S100 calcium binding protein A3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	153547329 - 153549372
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188015 (version 83.38)
Entrez gene	6274
UniProt	P33764 (UniProt - Evidence at protein level)
neXtProt	NX_P33764
Antibodypedia	S100A3 antibodies

PROTEIN BROWSER

S100A3-001	S100A3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
S100A3-001 ENSP00000357702 ENST00000368713	P33764 [Direct mapping] Protein S100-A3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] Show all	101 aa 11.7 kDa	No	0
S100A3-002 ENSP00000357701 ENST00000368712	P33764 [Direct mapping] Protein S100-A3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] Show all	101 aa 11.7 kDa	No	0