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General cytoplasmic staining in all cancer tissues. Strong staining in gliomas and urothelial cancers, other cancers were moderately stained. Additional weaker nuclear staining was also seen in several cancer tissues.
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]
MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005776 [autophagosome] GO:0005886 [plasma membrane] GO:0006914 [autophagy] GO:0016241 [regulation of macroautophagy] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031410 [cytoplasmic vesicle] GO:1900186 [negative regulation of clathrin-mediated endocytosis] GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process] GO:1904021 [negative regulation of G-protein coupled receptor internalization] GO:2000785 [regulation of autophagosome assembly]