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PLA2G4E

GENERAL INFORMATION

Gene name

 PLA2G4E

Gene description

 Phospholipase A2, group IVE

Protein class

 Enzymes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in melanocytes and squamous epithelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA041105
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA041105

GENE INFORMATION

Gene name

 PLA2G4E (HGNC Symbol)

Synonyms

 FLJ45651

Description

 Phospholipase A2, group IVE (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 41981582 - 42051190

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188089 (version 83.38)

Entrez gene

 123745

UniProt

 Q3MJ16 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q3MJ16

Antibodypedia

 PLA2G4E antibodies

PROTEIN BROWSER
PLA2G4E-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLA2G4E-001
ENSP00000382434
ENST00000399518
Q3MJ16 [Direct mapping]
Cytosolic phospholipase A2 epsilon
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
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GO:0004620 [phospholipase activity]
GO:0004623 [phospholipase A2 activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006644 [phospholipid metabolic process]
GO:0008152 [metabolic process]
GO:0009395 [phospholipid catabolic process]
GO:0036149 [phosphatidylinositol acyl-chain remodeling]
GO:0036150 [phosphatidylserine acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0046872 [metal ion binding]
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 868 aa
99.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.