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MESP2

GENERAL INFORMATION

Gene name

 MESP2

Gene description

 Mesoderm posterior bHLH transcription factor 2

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (U-2197)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MESP2 (HGNC Symbol)

Synonyms

 bHLHc6, SCDO2

Description

 Mesoderm posterior bHLH transcription factor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008]

Chromosome

 15

Cytoband

 q26.1

Chromosome location (bp)

 89760591 - 89778754

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188095 (version 83.38)

Entrez gene

 145873

UniProt

 Q0VG99 (UniProt - Evidence at protein level)

neXtProt

 NX_Q0VG99

Antibodypedia

 MESP2 antibodies

PROTEIN BROWSER
MESP2-001
MESP2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MESP2-001
ENSP00000342392
ENST00000341735
Q0VG99 [Direct mapping]
Mesoderm posterior protein 2
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Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007219 [Notch signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0046983 [protein dimerization activity]
GO:0070062 [extracellular exosome]
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 397 aa
41.8 kDa 		No 0
MESP2-002
ENSP00000452998
ENST00000560219
H0YKZ5 [Direct mapping]
Mesoderm posterior protein 2
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Predicted intracellular proteins
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 99 aa
10.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.