Hepatocellular carcinoms displayed moderate to strong cytoplasmic staining. Several cases of malignant carcinoid, melanomas, colorectal, ovarian, thyroid and hepatocellular cancer showed moderate cytoplasmic and/or nuclear staining. Remaining cancer tissues were weakly stained or negative.
AGRN (HGNC Symbol)
Agrin (HGNC Symbol)
Entrez gene summary
This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)