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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AGRN
  • TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AGRN

Gene description

Agrin

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including renal tubules and lung.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA040090
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA040090

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Hepatocellular carcinoms displayed moderate to strong cytoplasmic staining. Several cases of malignant carcinoid, melanomas, colorectal, ovarian, thyroid and hepatocellular cancer showed moderate cytoplasmic and/or nuclear staining. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

AGRN (HGNC Symbol)

Synonyms

AGRIN

Description

Agrin (HGNC Symbol)

Entrez gene summary

This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Chromosome

1

Cytoband

p36.33

Chromosome location (bp)

1020123 - 1056118

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000188157 (version 83.38)

Entrez gene

375790

UniProt

O00468 (UniProt - Evidence at protein level)

neXtProt

NX_O00468

Antibodypedia

AGRN antibodies

PROTEIN BROWSER

AGRN-001
AGRN-009
AGRN-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AGRN-001
ENSP00000368678
ENST00000379370
O00468 [Direct mapping]
Agrin Agrin N-terminal 110 kDa subunit Agrin C-terminal 110 kDa subunit Agrin C-terminal 90 kDa fragment Agrin C-terminal 22 kDa fragment
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0002162 [dystroglycan binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005605 [basal lamina]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0007009 [plasma membrane organization]
GO:0007165 [signal transduction]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0007603 [phototransduction, visible light]
GO:0008582 [regulation of synaptic growth at neuromuscular junction]
GO:0009986 [cell surface]
GO:0010469 [regulation of receptor activity]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030548 [acetylcholine receptor regulator activity]
GO:0031012 [extracellular matrix]
GO:0033691 [sialic acid binding]
GO:0035374 [chondroitin sulfate binding]
GO:0043113 [receptor clustering]
GO:0043202 [lysosomal lumen]
GO:0043236 [laminin binding]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0044281 [small molecule metabolic process]
GO:0045162 [clustering of voltage-gated sodium channels]
GO:0045202 [synapse]
GO:0045213 [neurotransmitter receptor metabolic process]
GO:0045887 [positive regulation of synaptic growth at neuromuscular junction]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050808 [synapse organization]
GO:0051491 [positive regulation of filopodium assembly]
GO:0070062 [extracellular exosome]
Show all
2045 aa
214.8 kDa
Yes 0
AGRN-009
ENSP00000400771
ENST00000419249
H0Y5U1 [Direct mapping]
Agrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
271 aa
28.7 kDa
No 0
AGRN-201
ENSP00000484607
ENST00000620552
A0A087X208 [Direct mapping]
Agrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0043113 [receptor clustering]
GO:0043236 [laminin binding]
Show all
1930 aa
202.3 kDa
No 0

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