Cell atlas - TMPPE - The Human Protein Atlas

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TMPPE

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TMPPE
Gene description	Transmembrane protein with metallophosphoesterase domain
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria & nucleoplasm.
RNA cell category	Cell line enriched (BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA027019
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria & nucleoplasm.

Main location

Nucleoplasm (approved), Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA027019	A-431	Nucleoplasm	Intensity
	HPA027019	A-431	Mitochondria
	HPA027019	U-2 OS	Nucleoplasm
	HPA027019	U-2 OS	Mitochondria
	HPA027019	U-251 MG	Nucleoplasm	Intensity
	HPA027019	U-251 MG	Cytosol

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA027019	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. TMPPE is mostly expressed during G1, and during S and/or G2.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Nucleoplasm

GENE INFORMATION
Gene name	TMPPE (HGNC Symbol)
Synonyms	FLJ45032
Description	Transmembrane protein with metallophosphoesterase domain (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p22.3
Chromosome location (bp)	33090421 - 33096801
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188167 (version 83.38)
Entrez gene	643853
UniProt	Q6ZT21 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZT21
Antibodypedia	TMPPE antibodies

PROTEIN BROWSER

TMPPE-001	TMPPE-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMPPE-001 ENSP00000343398 ENST00000342462	Q6ZT21 [Direct mapping] Transmembrane protein with metallophosphoesterase domain Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	453 aa 49.5 kDa	No	5
TMPPE-002 ENSP00000400715 ENST00000416695	Q6ZT21 [Direct mapping] Transmembrane protein with metallophosphoesterase domain Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	316 aa 34.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.