Expression of NCR3LG1 in cancer - Summary - The Human Protein Atlas

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NCR3LG1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NCR3LG1
Gene description	Natural killer cell cytotoxicity receptor 3 ligand 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HL-60, K-562)
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA024137
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024137

GENE INFORMATION
Gene name	NCR3LG1 (HGNC Symbol)
Synonyms	B7-H6, DKFZp686O24166
Description	Natural killer cell cytotoxicity receptor 3 ligand 1 (HGNC Symbol)
Entrez gene summary	B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
Chromosome	11
Cytoband	p15.1
Chromosome location (bp)	17351726 - 17377341
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188211 (version 83.38)
Entrez gene	374383
UniProt	Q68D85 (UniProt - Evidence at protein level)
neXtProt	NX_Q68D85
Antibodypedia	NCR3LG1 antibodies

PROTEIN BROWSER

NCR3LG1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCR3LG1-001 ENSP00000341637 ENST00000338965	Q68D85 [Direct mapping] Natural cytotoxicity triggering receptor 3 ligand 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0019028 [viral capsid] GO:0050776 [regulation of immune response] Show all	454 aa 50.8 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.