Expression of AGAP4 in cancer - Summary - The Human Protein Atlas

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AGAP4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AGAP4
Gene description	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA042490
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042490

GENE INFORMATION
Gene name	AGAP4 (HGNC Symbol)
Synonyms	AGAP8, CTGLF1, CTGLF5, Em:AC012044.1, MRIP2
Description	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q11.22
Chromosome location (bp)	45825594 - 45853875
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000188234 (version 83.38)
Entrez gene	119016
UniProt	Q96P64 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96P64
Antibodypedia	AGAP4 antibodies

PROTEIN BROWSER

AGAP4-001	AGAP4-002	AGAP4-201	AGAP4-202	AGAP4-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGAP4-001 ENSP00000392513 ENST00000448048	Q96P64 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	663 aa 73.1 kDa	No	0
AGAP4-002 ENSP00000468160 ENST00000492347	K7ER91 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 Show all	Predicted intracellular proteins Show all		137 aa 15.3 kDa	No	0
AGAP4-201 ENSP00000309985 ENST00000311652	A0A087WSV4 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	663 aa 73.1 kDa	No	0
AGAP4-202 ENSP00000483751 ENST00000616763	A0A087X0Z1 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	686 aa 75.6 kDa	No	0
AGAP4-203 ENSP00000478047 ENST00000618171	A0A087WTP8 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0043547 [positive regulation of GTPase activity] Show all	658 aa 72.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.