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PLA2G2A

GENERAL INFORMATION

Gene name

 PLA2G2A

Gene description

 Phospholipase A2, group IIA (platelets, synovial fluid)

Protein class

 Enzymes
FDA approved drug targets
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (Hep G2, RT4)
HPA (normal tissue):Tissue enhanced (colon, rectum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in paneth cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA015236
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (favourable).
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA015236

GENE INFORMATION

Gene name

 PLA2G2A (HGNC Symbol)

Synonyms

 PLA2B, PLA2L

Description

 Phospholipase A2, group IIA (platelets, synovial fluid) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 19975431 - 19980416

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188257 (version 83.38)

Entrez gene

 5320

UniProt

 P14555 (UniProt - Evidence at protein level)

neXtProt

 NX_P14555

Antibodypedia

 PLA2G2A antibodies

PROTEIN BROWSER
PLA2G2A-001
PLA2G2A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLA2G2A-001
ENSP00000364252
ENST00000375111
P14555 [Direct mapping]
Phospholipase A2, membrane associated
A0A024RA96 [Target identity:100%; Query identity:100%]
Phospholipase A(2)
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004623 [phospholipase A2 activity]
GO:0005509 [calcium ion binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0016042 [lipid catabolic process]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0036148 [phosphatidylglycerol acyl-chain remodeling]
GO:0036149 [phosphatidylinositol acyl-chain remodeling]
GO:0036150 [phosphatidylserine acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0044281 [small molecule metabolic process]
GO:0046473 [phosphatidic acid metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0047498 [calcium-dependent phospholipase A2 activity]
GO:0050729 [positive regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
Show all
 144 aa
16.1 kDa 		Yes 0
PLA2G2A-201
ENSP00000383364
ENST00000400520
P14555 [Direct mapping]
Phospholipase A2, membrane associated
A0A024RA96 [Target identity:100%; Query identity:100%]
Phospholipase A(2)
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004623 [phospholipase A2 activity]
GO:0005509 [calcium ion binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0016042 [lipid catabolic process]
GO:0030141 [secretory granule]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0035019 [somatic stem cell population maintenance]
GO:0036148 [phosphatidylglycerol acyl-chain remodeling]
GO:0036149 [phosphatidylinositol acyl-chain remodeling]
GO:0036150 [phosphatidylserine acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0042127 [regulation of cell proliferation]
GO:0044281 [small molecule metabolic process]
GO:0046473 [phosphatidic acid metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0047498 [calcium-dependent phospholipase A2 activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050678 [regulation of epithelial cell proliferation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050729 [positive regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
Show all
 144 aa
16.1 kDa 		Yes 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
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