Expression of FOCAD in cancer - Summary - The Human Protein Atlas

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FOCAD

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FOCAD
Gene description	Focadhesin
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA055015
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (unfavourable) and colorectal cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055015

GENE INFORMATION
Gene name	FOCAD (HGNC Symbol)
Synonyms	FLJ20375, KIAA1797
Description	Focadhesin (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	p21.3
Chromosome location (bp)	20658309 - 20995955
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188352 (version 83.38)
Entrez gene	54914
UniProt	Q5VW36 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VW36
Antibodypedia	FOCAD antibodies

PROTEIN BROWSER

FOCAD-001	FOCAD-002	FOCAD-012	FOCAD-013	FOCAD-014	FOCAD-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FOCAD-001 ENSP00000369599 ENST00000380249	Q5VW36 [Direct mapping] Focadhesin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005925 [focal adhesion] GO:0016021 [integral component of membrane] Show all	1801 aa 200.1 kDa	No	1
FOCAD-002 ENSP00000474915 ENST00000605086	S4R400 [Direct mapping] Focadhesin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	1237 aa 136.4 kDa	No	1
FOCAD-012 ENSP00000475075 ENST00000603044	S4R450 [Direct mapping] Focadhesin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		128 aa 13.9 kDa	No	0
FOCAD-013 ENSP00000474563 ENST00000604254	S4R3N8 [Direct mapping] Focadhesin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		180 aa 19.4 kDa	Yes	0
FOCAD-014 ENSP00000474683 ENST00000603695	S4R3S9 [Direct mapping] Focadhesin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 10.7 kDa	No	0
FOCAD-201 ENSP00000344307 ENST00000338382	Q5VW36 [Direct mapping] Focadhesin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005925 [focal adhesion] GO:0016021 [integral component of membrane] Show all	1801 aa 200.1 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.