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PDCD1

GENERAL INFORMATION

Gene name

 PDCD1

Gene description

 Programmed cell death 1

Protein class

 CD markers
Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node)
GTEx:Tissue enhanced (spleen)
FANTOM5:Tissue enhanced (appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of cells in lymphoid germinal centers.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA035981 , CAB038418
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION

Gene name

 PDCD1 (HGNC Symbol)

Synonyms

 CD279, hSLE1, PD-1, PD1, SLEB2

Description

 Programmed cell death 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 241849881 - 241858908

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188389 (version 83.38)

Entrez gene

 5133

UniProt

 Q15116 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15116

Antibodypedia

 PDCD1 antibodies

PROTEIN BROWSER
PDCD1-001
PDCD1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDCD1-001
ENSP00000335062
ENST00000334409
Q15116 [Direct mapping]
Programmed cell death protein 1
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
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GO:0002644 [negative regulation of tolerance induction]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0009897 [external side of plasma membrane]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0070234 [positive regulation of T cell apoptotic process]
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 288 aa
31.6 kDa 		No 1
PDCD1-003
ENSP00000340808
ENST00000343705
H0Y2W6 [Direct mapping]
Programmed cell death protein 1
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 123 aa
13.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.