Expression of GPR21 in cancer - Summary - The Human Protein Atlas

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GPR21

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPR21
Gene description	G protein-coupled receptor 21
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA041651
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041651

GENE INFORMATION
Gene name	GPR21
Synonyms
Description	G protein-coupled receptor 21 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q33.2
Chromosome location (bp)	123034527 - 123035696
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000188394 (version 83.38)
Entrez gene
UniProt	Q99679 (UniProt - Evidence at transcript level)
neXtProt	NX_Q99679
Antibodypedia	GPR21 antibodies

PROTEIN BROWSER

GPR21-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR21-001 ENSP00000362746 ENST00000373642	Q99679 [Direct mapping] Probable G-protein coupled receptor 21 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007606 [sensory perception of chemical stimulus] GO:0008227 [G-protein coupled amine receptor activity] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0040018 [positive regulation of multicellular organism growth] GO:0042593 [glucose homeostasis] GO:0046627 [negative regulation of insulin receptor signaling pathway] Show all	349 aa 39.5 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.