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SLC24A5

GENERAL INFORMATION

Gene name

 SLC24A5

Gene description

 Solute carrier family 24 (sodium/potassium/calcium exchanger), member 5

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (melanoma)
HPA (cell line):Cell line enriched (SK-MEL-30)
HPA (normal tissue):Group enriched (skin, testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SLC24A5 (HGNC Symbol)

Synonyms

 JSX, OCA6

Description

 Solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the potassium-dependent sodium/calcium exchanger family and encodes an intracellular membrane protein with 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments. Sequence variation in this gene has been associated with differences in skin pigmentation. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q21.1

Chromosome location (bp)

 48120972 - 48142672

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188467 (version 83.38)

Entrez gene

 283652

UniProt

 Q71RS6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q71RS6

Antibodypedia

 SLC24A5 antibodies

PROTEIN BROWSER
SLC24A5-001
SLC24A5-002
SLC24A5-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC24A5-001
ENSP00000341550
ENST00000341459
Q71RS6 [Direct mapping]
Sodium/potassium/calcium exchanger 5
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005802 [trans-Golgi network]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0015293 [symporter activity]
GO:0016021 [integral component of membrane]
GO:0030955 [potassium ion binding]
GO:0031402 [sodium ion binding]
GO:0032588 [trans-Golgi network membrane]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042470 [melanosome]
GO:0048022 [negative regulation of melanin biosynthetic process]
GO:0050896 [response to stimulus]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
Show all
 500 aa
54.9 kDa 		Yes >9
SLC24A5-002
ENSP00000453395
ENST00000482911
H0YLZ0 [Direct mapping]
Sodium/potassium/calcium exchanger 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005802 [trans-Golgi network]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0048021 [regulation of melanin biosynthetic process]
Show all
 122 aa
13.9 kDa 		Yes 1
SLC24A5-004
ENSP00000389966
ENST00000449382
Q71RS6 [Direct mapping]
Sodium/potassium/calcium exchanger 5
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005802 [trans-Golgi network]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0015293 [symporter activity]
GO:0016021 [integral component of membrane]
GO:0030955 [potassium ion binding]
GO:0031402 [sodium ion binding]
GO:0032588 [trans-Golgi network membrane]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042470 [melanosome]
GO:0050896 [response to stimulus]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
Show all
 440 aa
48 kDa 		Yes 9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.