Cell atlas - LCTL - The Human Protein Atlas

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LCTL

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Plasma membrane

Human cell
	Endoplasmic Reticulum
	Plasma Membrane

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GENERAL INFORMATION
Gene name	LCTL
Gene description	Lactase-like
Protein class	Cancer-related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the endoplasmic reticulum.
RNA cell category	Cell line enhanced (U-2 OS)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA071640
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the endoplasmic reticulum.

Main location

Plasma membrane (approved)

Additional location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071640	RH-30	Plasma membrane
	HPA071640	U-2 OS	Plasma membrane
	HPA071640	U-251 MG	Endoplasmic reticulum
	HPA071640	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	LCTL (HGNC Symbol)
Synonyms	FLJ33279, KLG, KLPH
Description	Lactase-like (HGNC Symbol)
Entrez gene summary	This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	66547179 - 66565979
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188501 (version 83.38)
Entrez gene	197021
UniProt	Q6UWM7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UWM7
Antibodypedia	LCTL antibodies

PROTEIN BROWSER

LCTL-001	LCTL-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LCTL-001 ENSP00000343490 ENST00000341509	Q6UWM7 [Direct mapping] Lactase-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005903 [brush border] GO:0005975 [carbohydrate metabolic process] GO:0016021 [integral component of membrane] Show all	567 aa 65.1 kDa	Yes	1
LCTL-003 ENSP00000445419 ENST00000537670	Q6UWM7 [Direct mapping] Lactase-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0005789 [endoplasmic reticulum membrane] GO:0005975 [carbohydrate metabolic process] GO:0016021 [integral component of membrane] Show all	394 aa 45.7 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.