Expression of NCCRP1 in cancer - Summary

GENERAL INFORMATION
Gene name	NCCRP1
Gene description	Non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (SK-BR-3)
HPA (normal tissue):	Group enriched (esophagus, skin, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in squamous epithelium, epididymis, exocrine pancreatic cells and renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA052812
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA052812

GENE INFORMATION
Gene name	NCCRP1 (HGNC Symbol)
Synonyms	FBXO50, LOC342897, NCCRP-1
Description	Non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	39196961 - 39201884
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188505 (version 83.38)
Entrez gene	342897
UniProt	Q6ZVX7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZVX7
Antibodypedia	NCCRP1 antibodies

PROTEIN BROWSER

NCCRP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCCRP1-001 ENSP00000342137 ENST00000339852	Q6ZVX7 [Direct mapping] F-box only protein 50 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0008284 [positive regulation of cell proliferation] GO:0070062 [extracellular exosome] Show all	275 aa 30.8 kDa	No	0