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DUSP28

GENERAL INFORMATION

Gene name

 DUSP28

Gene description

 Dual specificity phosphatase 28

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression in several cases combined with membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA047456 , CAB069448
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047456
CAB069448

GENE INFORMATION

Gene name

 DUSP28 (HGNC Symbol)

Synonyms

 DUSP26, VHP

Description

 Dual specificity phosphatase 28 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 240560054 - 240564014

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188542 (version 83.38)

Entrez gene

 285193

UniProt

 Q4G0W2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q4G0W2

Antibodypedia

 DUSP28 antibodies

PROTEIN BROWSER
DUSP28-001
DUSP28-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUSP28-001
ENSP00000385885
ENST00000405954
Q4G0W2 [Direct mapping]
Dual specificity phosphatase 28
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0004725 [protein tyrosine phosphatase activity]
GO:0005622 [intracellular]
GO:0006470 [protein dephosphorylation]
GO:0007254 [JNK cascade]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
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 176 aa
18.3 kDa 		No 0
DUSP28-201
ENSP00000344235
ENST00000343217
Q4G0W2 [Direct mapping]
Dual specificity phosphatase 28
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005622 [intracellular]
GO:0006470 [protein dephosphorylation]
GO:0007254 [JNK cascade]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
 176 aa
18.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.