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NDOR1

GENERAL INFORMATION

Gene name

 NDOR1

Gene description

 NADPH dependent diflavin oxidoreductase 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA024504
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA024504

GENE INFORMATION

Gene name

 NDOR1 (HGNC Symbol)

Synonyms

 bA350O14.9, NR1

Description

 NADPH dependent diflavin oxidoreductase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 137205670 - 137217009

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188566 (version 83.38)

Entrez gene

 27158

UniProt

 Q9UHB4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHB4

Antibodypedia

 NDOR1 antibodies

PROTEIN BROWSER
NDOR1-001
NDOR1-002
NDOR1-003
NDOR1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NDOR1-001
ENSP00000343344
ENST00000344894
Q9UHB4 [Direct mapping]
NADPH-dependent diflavin oxidoreductase 1
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008219 [cell death]
GO:0010181 [FMN binding]
GO:0016226 [iron-sulfur cluster assembly]
GO:0016491 [oxidoreductase activity]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0036245 [cellular response to menadione]
GO:0044281 [small molecule metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
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 597 aa
66.8 kDa 		No 0
NDOR1-002
ENSP00000360576
ENST00000371521
Q9UHB4 [Direct mapping]
NADPH-dependent diflavin oxidoreductase 1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008219 [cell death]
GO:0010181 [FMN binding]
GO:0016226 [iron-sulfur cluster assembly]
GO:0016491 [oxidoreductase activity]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0036245 [cellular response to menadione]
GO:0044281 [small molecule metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
Show all
 606 aa
67.7 kDa 		No 0
NDOR1-003
ENSP00000394309
ENST00000427047
Q9UHB4 [Direct mapping]
NADPH-dependent diflavin oxidoreductase 1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008219 [cell death]
GO:0010181 [FMN binding]
GO:0016226 [iron-sulfur cluster assembly]
GO:0016491 [oxidoreductase activity]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0036245 [cellular response to menadione]
GO:0044281 [small molecule metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
Show all
 521 aa
58.5 kDa 		No 0
NDOR1-004
ENSP00000389905
ENST00000458322
Q9UHB4 [Direct mapping]
NADPH-dependent diflavin oxidoreductase 1
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008219 [cell death]
GO:0010181 [FMN binding]
GO:0016226 [iron-sulfur cluster assembly]
GO:0016491 [oxidoreductase activity]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0036245 [cellular response to menadione]
GO:0044281 [small molecule metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
Show all
 590 aa
65.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.