Fields »
ABOUT
HELP
BLOG
SLC4A5

GENERAL INFORMATION

Gene name

 SLC4A5

Gene description

 Solute carrier family 4 (sodium bicarbonate cotransporter), member 5

Protein class

 Cancer-related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (thyroid cancer)
HPA (cell line):Cell line enhanced (U-266/70)
HPA (normal tissue):Group enriched (testis, thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissue types, including testis and kidney.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA036621
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (thyroid cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036621

GENE INFORMATION

Gene name

 SLC4A5 (HGNC Symbol)

Synonyms

 NBC4

Description

 Solute carrier family 4 (sodium bicarbonate cotransporter), member 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p13.1

Chromosome location (bp)

 74216242 - 74343414

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188687 (version 83.38)

Entrez gene

 57835

UniProt

 Q9BY07 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9BY07

Antibodypedia

 SLC4A5 antibodies

PROTEIN BROWSER
SLC4A5-001
SLC4A5-002
SLC4A5-003
SLC4A5-006
SLC4A5-007
SLC4A5-008
SLC4A5-009
SLC4A5-012
SLC4A5-201
SLC4A5-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC4A5-001
ENSP00000366861
ENST00000377634
Q9BY07 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
Show all
GO:0003014 [renal system process]
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 1137 aa
126.3 kDa 		No >9
SLC4A5-002
ENSP00000377587
ENST00000394019
Q9BY07 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Show all
GO:0003014 [renal system process]
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 1121 aa
124.6 kDa 		No >9
SLC4A5-003
ENSP00000366859
ENST00000377632
Q9BY07 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
Show all
GO:0003014 [renal system process]
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 1040 aa
115.2 kDa 		No 9
SLC4A5-006
ENSP00000405678
ENST00000425249
E7EQT3 [Direct mapping]
Anion exchange protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
Show all
GO:0003014 [renal system process]
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0098656 [anion transmembrane transport]
Show all
 964 aa
105.7 kDa 		No 6
SLC4A5-007
ENSP00000351513
ENST00000358683
Q9BY07 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
Show all
GO:0003014 [renal system process]
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 1019 aa
113.4 kDa 		No >9
SLC4A5-008
ENSP00000399319
ENST00000436454
C9JW32 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Show all
GO:0003014 [renal system process]
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0098656 [anion transmembrane transport]
Show all
 129 aa
14.5 kDa 		No 0
SLC4A5-009
ENSP00000407550
ENST00000444570
C9JU12 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Show all
GO:0003014 [renal system process]
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0098656 [anion transmembrane transport]
Show all
 145 aa
16.4 kDa 		No 0
SLC4A5-012
ENSP00000414162
ENST00000432728
C9JNL6 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Show all
GO:0003014 [renal system process]
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0098656 [anion transmembrane transport]
Show all
 122 aa
14.2 kDa 		No 0
SLC4A5-201
ENSP00000251768
ENST00000346834
Q9BY07 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Show all
GO:0002064 [epithelial cell development]
GO:0003014 [renal system process]
GO:0003073 [regulation of systemic arterial blood pressure]
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0010468 [regulation of gene expression]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0033326 [cerebrospinal fluid secretion]
GO:0035725 [sodium ion transmembrane transport]
GO:0048311 [mitochondrion distribution]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0060041 [retina development in camera-type eye]
GO:0098656 [anion transmembrane transport]
Show all
 1137 aa
126.3 kDa 		No >9
SLC4A5-202
ENSP00000395804
ENST00000423644
Q9BY07 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
Show all
GO:0003014 [renal system process]
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 1121 aa
124.6 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.