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FZD9

GENERAL INFORMATION

Gene name

 FZD9

Gene description

 Frizzled class receptor 9

Protein class

 CD markers
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (melanoma)
HPA (cell line):Cell line enhanced (HEK93, NTERA-2)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 FZD9 (HGNC Symbol)

Synonyms

 CD349, FZD3

Description

 Frizzled class receptor 9 (HGNC Symbol)

Entrez gene summary

 Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q11.23

Chromosome location (bp)

 73433783 - 73436120

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000188763 (version 83.38)

Entrez gene

 8326

UniProt

 O00144 (UniProt - Evidence at transcript level)

neXtProt

 NX_O00144

Antibodypedia

 FZD9 antibodies

PROTEIN BROWSER
FZD9-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FZD9-001
ENSP00000345785
ENST00000344575
O00144 [Direct mapping]
Frizzled-9
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CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family fz/smo receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007399 [nervous system development]
GO:0007405 [neuroblast proliferation]
GO:0007611 [learning or memory]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016055 [Wnt signaling pathway]
GO:0017147 [Wnt-protein binding]
GO:0030183 [B cell differentiation]
GO:0031527 [filopodium membrane]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0042813 [Wnt-activated receptor activity]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0060070 [canonical Wnt signaling pathway]
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 591 aa
64.5 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.