Expression of OPTC in cancer - Summary - The Human Protein Atlas

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OPTC

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OPTC
Gene description	Opticin
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in vitreous of the eye.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining but no internal RNA data available for correlation. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA034951 , HPA034952
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034951	HPA034952

GENE INFORMATION
Gene name	OPTC
Synonyms
Description	Opticin (HGNC Symbol)
Entrez gene summary	Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	203494143 - 203508864
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188770 (version 83.38)
Entrez gene	26254
UniProt	Q9UBM4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBM4
Antibodypedia	OPTC antibodies

PROTEIN BROWSER

OPTC-001	OPTC-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OPTC-001 ENSP00000356191 ENST00000367222	Q9UBM4 [Direct mapping] Opticin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0016525 [negative regulation of angiogenesis] Show all	332 aa 37.3 kDa	Yes	0
OPTC-002 ENSP00000399491 ENST00000448911	Q5T2G3 [Direct mapping] Opticin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	174 aa 19.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.