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ADRB3

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GENERAL INFORMATION

Gene name

 ADRB3

Gene description

 Adrenoceptor beta 3

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ADRB3

Synonyms

Description

 Adrenoceptor beta 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]

Chromosome

 8

Cytoband

 p11.23

Chromosome location (bp)

 37962991 - 37966965

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188778 (version 83.38)

Entrez gene

 155

UniProt

 P13945 (UniProt - Evidence at protein level)

neXtProt

 NX_P13945

Antibodypedia

 ADRB3 antibodies

PROTEIN BROWSER
ADRB3-001
ADRB3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADRB3-001
ENSP00000343782
ENST00000345060
P13945 [Direct mapping]
Beta-3 adrenergic receptor
A8KAG8 [Target identity:100%; Query identity:100%]
Adrenergic, beta-3-, receptor, isoform CRA_b; cDNA FLJ78531, highly similar to Homo sapiens adrenergic, beta-3-, receptor (ADRB3), mRNA; cDNA, FLJ94487, Homo sapiens adrenergic, beta-3-, receptor (ADRB3), mRNA
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001659 [temperature homeostasis]
GO:0002024 [diet induced thermogenesis]
GO:0002025 [vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004939 [beta-adrenergic receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007267 [cell-cell signaling]
GO:0007568 [aging]
GO:0009409 [response to cold]
GO:0015052 [beta3-adrenergic receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031649 [heat generation]
GO:0031699 [beta-3 adrenergic receptor binding]
GO:0040015 [negative regulation of multicellular organism growth]
GO:0042755 [eating behavior]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0046677 [response to antibiotic]
GO:0050873 [brown fat cell differentiation]
GO:0051379 [epinephrine binding]
GO:0051380 [norepinephrine binding]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
Show all
 408 aa
43.5 kDa 		No 7
ADRB3-201
ENSP00000480325
ENST00000614635
P13945 [Direct mapping]
Beta-3 adrenergic receptor
A8KAG8 [Target identity:100%; Query identity:100%]
Adrenergic, beta-3-, receptor, isoform CRA_b; cDNA FLJ78531, highly similar to Homo sapiens adrenergic, beta-3-, receptor (ADRB3), mRNA; cDNA, FLJ94487, Homo sapiens adrenergic, beta-3-, receptor (ADRB3), mRNA
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001659 [temperature homeostasis]
GO:0002025 [vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004939 [beta-adrenergic receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007267 [cell-cell signaling]
GO:0015052 [beta3-adrenergic receptor activity]
GO:0016021 [integral component of membrane]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0051379 [epinephrine binding]
GO:0051380 [norepinephrine binding]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
Show all
 408 aa
43.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.